Research on Amphetamine-type Stimulants

 

Garton, D.R., and Lizardi-Ortiz, J.E. D-Amphetamine Modulation of Dorsal Striatal Dopamine Release is Temperature Dependent: Experimental Considerations.

Manuscript in preparation.

 

Garton, D.R., Ross, S.G., Maldonado-Hernández, R., Quick, M., Lasalde-Dominicci, J.A., and Lizardi-Ortiz, J.E. Amphetamine Isomers Inhibit Homomeric α7 Nicotinic Receptor through a Competitive Mechanism and within the Intoxication Levels in Humans. 2019, Neuropharmacology, 144, 172-183.

DOI: 10.1016/j.neuropharm.2018.10.032.

 

Research on Dopamine System

 

Mingote, S., Chuhma, N., Kalmbach, A., Thomsen, G.M., Wang, Y., Mihali, A., Sferrazza, C.E., Zucker-Scharff, I., Siena, A.C., Welch, M.G., Lizardi-Ortiz, J., Sulzer, D., Moore, H., Gaisler-Salomon, I., Rayport, S. Dopamine neuron dependent behaviors mediated by glutamate cotransmission. 2017, eLife, 6:e27566. DOI: 10.7554/eLife.27566.

 

Pereira, D., Schmitz, Y., Mészáros, J., Merchant, P., Hu, G., Li, G., Henke, A., Lizardi-Ortiz, J.E., Karpowicz Jr., R., Sonders, M., Kanter, E., Rodriguez, P., Mosharov, E., Sames, D., and Sulzer, D. Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum, 2016, 19(4), Nature Neuroscience, 578-586.

DOI: 10.1038/nn.4252.

 

Anzalone, A., Lizardi-Ortiz, J.E., Ramos, M., De Mei, C., Hopf, F., Iaccarino, C., Halbout, B., Jacobsen, J., Kinoshita, C., Welter, M., Caron, M., Bonci, A., Sulzer, D., and Borrelli, E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. 2012, 32(36), Journal of Neuroscience, 9023-34.

DOI: 10.1523/JNEUROSCI.0918-12.2012.

 

Research on Parkinsonims & Movement Disorders

 

Kharkwal, G., Brami-Cherrier, K., Lizardi-Ortiz, J.E., Nelson, A., Ramos, M., Del Barrio, D., Sulzer, D., Krietzer, A., and Borrelli, E. Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons, 2016, 91(1), Neuron, 67-78.

DOI: 10.1016/j.neuron.2016.06.014.

 

Schmitz, Y., Barnard, C., Mrejeru, A., Lizardi-Ortiz, J.E., Klein, Z., Lindsley, C.W., and Sulzer, D. Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons. 2013, 33(42), Journal of Neuroscience, 16778-89.

DOI: 10.1523/JNEUROSCI.3041-12.2013.

 

Research on Muscarinic Receptors

 

Foster, D.J., Gentry, P.R., Lizardi-Ortiz, J.E., Bridges, T.M., Wood, M.R., Niswender, C.M., Sulzer, D., Lindsley, C.W., Xiang, Z. Conn, P.J. M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location. 2014, 34(9), Journal of Neuroscience, 3253-62.

DOI: 10.1523/JNEUROSCI.4896-13.2014.

 

Bendor, J., Lizardi-Ortiz, J.E., Westphalen, R.I., Brandstetter, M., Hemmings Jr, H.C., Sulzer, D., Flajolet, M., and Greengard, P. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. 2010, 29(16), The EMBO Journal, 2813–26.

DOI: 10.1038/emboj.2010.154.

 

Research on Nicotinic Receptors

 

Lizardi-Ortiz, J.E., Hyzinski-García, M.C., Fernández-Genera, J.L., Osorio-Martínez, K.M., Velásquez-Rivera, E., Valle-Avilés, F.L., Lasalde-Dominicci, J.A.  Aromaticity at the Water/Hydrophobic Core Interface of the Membrane: Consequences on the Nicotinic Acetylcholine Receptor.  2008, Channels, 2(3), 191–201.

DOI: 10.4161/chan.2.3.6385.

 

Lopez-Hernández, G.Y., Sanchez-Padilla, J., Ortiz-Acevedo, A., Lizardi-Ortiz, J.E., Salas-Vincenty, J., Rojas, L.V., Lasalde-Dominicci, J.A. Nicotine-induced Up-regulation and Desensitization of α4β2 Neuronal Nicotinic Receptors Depend on Subunit Ratio. Journal of Biological Chemistry, 2004, 279(36), 38007–15. DOI: 10.1074/jbc.M403537200.

 

Research on Alcohol (Collaboration with Dr. Se Joon Choi, Research Foundation for Mental Hygiene)

 

Lizardi-Ortiz, J.E., Marti-Prats, L., Sung, K.W., and Choi, S.J. Acute Ethanol Inhibits Ionotropic Glutamate Receptor Neurotransmission in the Dorsolateral Striatum by a Dopamine-independent Mechanism. Manuscript in preparation.

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Research on Pumilio (Collaboration with Dr. José Agosto, University of Puerto Rico, Río Piedras)

 

Rodríguez-Cordero, J.A., Dorta Avilés, M., Rodriguez-Fernandez, I.A., Ghezzi, A., Lizardi-Ortiz, J.E., Agosto-Rivera, J.L. Peripheral modulation of Pumilio in Intestinal Stem Cells and Corpus Allatum Affects Sleep Latency in Drosophila. PLoS One, 2026, 21(3): e0337303.

DOI: 10.1371/journal.pone.0337303.

 

Rodríguez-Cordero, J.A., et al., Lizardi-Ortiz, J.E., Agosto-Rivera, J.L. Identification and Screening of Potential Inhibitor Candidates for the RNA-binding, Post-transcriptional Regulator: Pumilio 2.

Manuscript in preparation.