Research on Amphetamine-type Stimulants

 

Garton, D.R., Rodríguez-Cordero, J., Fernández-Rodríguez, E., and Lizardi-Ortiz, J.E. D-Amphetamine Modulation of Dorsal Striatal Dopamine Release is Temperature Dependent: Experimental Considerations. Manuscript in preparation.

 

Garton, D.R., Ross, S.G., Maldonado-Hernández, R., Quick, M., Lasalde-Dominicci, J.A., and Lizardi-Ortiz, J.E. Amphetamine Isomers Inhibit Homomeric α7 Nicotinic Receptor through a Competitive Mechanism and within the Intoxication Levels in Humans. 2019, Neuropharmacology, 144, 172-183.

DOI: 10.1016/j.neuropharm.2018.10.032.

 

Research on Dopamine System

 

Mingote, S., Chuhma, N., Kalmbach, A., Thomsen, G.M., Wang, Y., Mihali, A., Sferrazza, C.E., Zucker-Scharff, I., Siena, A.C., Welch, M.G., Lizardi-Ortiz, J., Sulzer, D., Moore, H., Gaisler-Salomon, I., Rayport, S. Dopamine neuron dependent behaviors mediated by glutamate cotransmission. 2017, eLife, 6:e27566. DOI: 10.7554/eLife.27566.

 

Pereira, D., Schmitz, Y., Mészáros, J., Merchant, P., Hu, G., Li, G., Henke, A., Lizardi-Ortiz, J.E., Karpowicz Jr., R., Sonders, M., Kanter, E., Rodriguez, P., Mosharov, E., Sames, D., and Sulzer, D. Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum, 2016, 19(4), Nature Neuroscience, 578-586.

DOI: 10.1038/nn.4252.

 

Anzalone, A., *Lizardi-Ortiz, J.E., Ramos, M., De Mei, C., Hopf, F., Iaccarino, C., Halbout, B., Jacobsen, J., Kinoshita, C., Welter, M., Caron, M., Bonci, A., Sulzer, D., and Borrelli, E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. 2012, 32(36), Journal of Neuroscience, 9023-34.

DOI: 10.1523/JNEUROSCI.0918-12.2012.

 

Research on Parkinsonims & Movement Disorders

 

Kharkwal, G., Brami-Cherrier, K., Lizardi-Ortiz, J.E., Nelson, A., Ramos, M., Del Barrio, D., Sulzer, D., Krietzer, A., and Borrelli, E. Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons, 2016, 91(1), Neuron, 67-78.

DOI: 10.1016/j.neuron.2016.06.014.

 

Schmitz, Y., Barnard, C., Mrejeru, A., Lizardi-Ortiz, J.E., Klein, Z., Lindsley, C.W., and Sulzer, D. Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons. 2013, 33(42), Journal of Neuroscience, 16778-89.

DOI: 10.1523/JNEUROSCI.3041-12.2013.

 

Research on Muscarinic Receptors

 

Foster, D.J., Gentry, P.R., Lizardi-Ortiz, J.E., Bridges, T.M., Wood, M.R., Niswender, C.M., Sulzer, D., Lindsley, C.W., Xiang, Z. Conn, P.J. M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location. 2014, 34(9), Journal of Neuroscience, 3253-62.

DOI: 10.1523/JNEUROSCI.4896-13.2014.

 

Bendor, J., Lizardi-Ortiz, J.E., Westphalen, R.I., Brandstetter, M., Hemmings Jr, H.C., Sulzer, D., Flajolet, M., and Greengard, P. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. 2010, 29(16), The EMBO Journal, 2813–26.

DOI: 10.1038/emboj.2010.154.

 

Research on Nicotinic Receptors

 

Lizardi-Ortiz, J.E., Hyzinski-García, M.C., Fernández-Genera, J.L., Osorio-Martínez, K.M., Velásquez-Rivera, E., Valle-Avilés, F.L., Lasalde-Dominicci, J.A.  Aromaticity at the Water/Hydrophobic Core Interface of the Membrane: Consequences on the Nicotinic Acetylcholine Receptor.  2008, Channels, 2(3), 191–201.

DOI: 10.4161/chan.2.3.6385.

 

Lopez-Hernández, G.Y., Sanchez-Padilla, J., Ortiz-Acevedo, A., Lizardi-Ortiz, J.E., Salas-Vincenty, J., Rojas, L.V., Lasalde-Dominicci, J.A. Nicotine-induced Up-regulation and Desensitization of α4β2 Neuronal Nicotinic Receptors Depend on Subunit Ratio. Journal of Biological Chemistry, 2004, 279(36), 38007–15. DOI: 10.1074/jbc.M403537200.

 

Research on Alcohol

 

Lizardi-Ortiz, J.E., Marti-Prats, L., Rodríguez-Cordero, J., Fernández-Rodríguez, E., Sung, K.W., and Choi, S.J. Acute Ethanol Inhibits Ionotropic Glutamate Synaptic Transmission in Dorsolateral Striatum by a Dopamine- and Acetylcholine-Independent Mechanism. Manuscript in preparation.